What are the side effects of clotrimazole

ClotrimazoleDrug groupsAntifungal drugsAzole antifungal agents Clotrimazole is an antifungal agent from the group of azole antifungal agents with antibacterial properties. It is used for the external treatment of fungal skin infections, for example athlete's foot and diaper rash. In the form of vaginal tablets and creams, it is used to treat vaginal thrush. Local skin irritation or hypersensitivity reactions can occur as undesirable effects.

synonym: ClotrimazolumPhEur


Clotrimazole is available as cream, cream, ointment, spray, in the form of vaginal tablets and as a vaginal cream alone or in combination with other active ingredients (e.g. Canesten®, Gyno-Canesten®, Imacort®, Imazol®, Triderm®). It has been approved in Switzerland since 1973.

Structure and properties

Clotrimazole (C.22H17ClN2, Mr = 344.8 g / mol) is a chlorinated phenylmethylimidazole derivative. It is available as a white to pale yellow powder that is practically insoluble in water.


Clotrimazole (ATC D01AC01) has antifungal properties against dermatophytes, yeasts, molds and other fungi. It also has antibacterial properties. The effects are based on the inhibition of ergosterol synthesis, an essential component of the fungal cell membrane.


For the treatment of skin fungal infections with dermatophytes, yeasts, molds and other fungi. In the form of vaginal tablets or as vaginal cream, clotrimazole is used for vaginal thrush and as an additional treatment for trichomoniasis.


According to the specialist information. To treat a fungal skin infection, the medicine is applied two to three times a day. The treatment should be continued for a few days after the improvement.


The complete precautionary measures can be found in the product information sheet.


Clotrimazole can reverse the effects of polyenes such as amphotericin B when applied externally at the same time. If used vaginally, the effectiveness of condoms and diaphragms can be impaired.

unwanted effects

Possible adverse effects of treatment are hypersensitivity reactions and local reactions.

see also

Azole antifungals, fungal infections, vaginal thrush

  • Medicinal product information (CH, D)
  • European Pharmacopoeia PhEur
  • swell
  • Sawyer P.R., Brogden R.N., Pinder R.M., Speight T.M., Avery. Clotrimazole: a review of its antifungal activity and therapeutic efficacy. Drugs, 1975, 9 (6), 424-47 Pubmed

Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.

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