How do peripheral and integral proteins differ?
Membranes contain proteins
Peripheral and integral membrane proteins
A lipid bilayer with proteins
Now I've got a little nostalgic again and have taken an old picture that I made for the basic biology lecture (Prof. Heckmann) in 1979. The lettering is up to date, however.
This figure clearly shows a lipid bilayer in which various proteins are embedded. Basically, one can differentiate between peripheral proteins and integral proteins. The peripheral proteins are only superimposed on the membrane, and calcium ions can play an important role as "putty". The integral proteins run through both layers of the lipid bilayer. One of the integral proteins shown here even contains a channel that runs through the entire protein, a pore, so to speak. The cell can exchange substances with the external medium through this channel. Many substances cannot pass through the lipid bilayer, although the individual lipid molecules are definitely mobile, as we have already seen on the previous pages.
What the figure also shows are the many sugar molecules that are on the lipids and also on the proteins - but only on the outside of the membrane. These sugar molecules play an important role in cell recognition and in the interaction of the various cells - but I don't want to go into that on this page.
A three-dimensional representation of the cell membrane
In this picture you can see a three-dimensional representation of the cell membrane with an external peripheral protein and an integral protein. This drawing also shows that the membrane proteins have hydrophilic and lipophilic regions with which they can anchor themselves well in the cell membrane.
Anchoring the proteins in the membrane
On this subject, I would like to introduce you to a small task that I developed from an illustration in a school book. Consider the following amino acid chain:
Now we determine which of these amino acids are polar and use colors to identify the polar acidic, polar neutral and polar basic amino acids:
Now we assume that this amino acid sequence coils up as an alpha helix. To do this, we print out the primary structure in color, cut it out as a long strip and wrap the strip around a thick pencil so that one turn comprises 3.6 amino acids on average - that is the exact value for an alpha helix.
The amino acids wrapped around my left index finger
Oh, I'm just seeing that my left index finger is almost the correct diameter. So I wrapped the cut out strip around my left index finger and then scanned it. You can see the impressive result above. Four of the seven polar amino acids are on the same side of the alpha helix.
It's even better with a thick ballpoint pen
If I wrap the strip around a thick ballpoint pen with a slightly smaller diameter, you can even see all seven polar amino acids on one side of the helix.
The alpha helix, which results from the amino acids, has a polar side and a non-polar side. You can't do much with that alone. But if several such helices come together, the result is an interesting structure, which I would also like to show you.
Seven alpha helices form a hydrophilic channel
The figure above shows a more complex integral membrane protein from above. The seven alpha helices with their lipophilic and hydrophilic areas are easy to see. The hydrophilic areas are oriented in such a way that a hydrophilic channel is formed through which water, water-soluble molecules or ions can pass through the cell membrane. Outwardly, however, this structure of seven helices is lipophilic and can therefore be anchored well in the lipid double layer.
- What is a colubrid snake
- What kinds of gossips are there
- How is fashion design at Sharda University
- Is South Korea better off than Taiwan
- Are Akira Kurosawa films worth watching
- What are the remedies for dry cought
- Is S400 really powerful
- How do little boys dress?
- Coarse sand is the same as Badarpur
- Which shampoo ingredients are harmful?
- Is grass renewable
- Lose 10 pounds a lot
- Was Einstein an alien?
- Why don't jellyfish reproduce asexually?
- The transistors obey Ohm's law
- How do money loans make money
- How can we measure religion
- Are there free tennis courts in Berlin
- Why is Buddha called the great doctor
- Where is Kudremukh in India
- How do I install TestRPC on Windows
- Should I get the Quora app?
- What is a chemical diet
- Why shouldn't you mow wet grass?