What are the benefits of oral medication

drug

Most drugs are swallowed.

This is the most commonly used method of administering a drug. After swallowing the drug, the active ingredient dissolves in the stomach or small intestine. From there it is absorbed through the gastric and intestinal mucosa and fed into the bloodstream. However, the medicinal substance must pass two stations before it can enter the great bloodstream (body cycle):
  1. Liver: This process can be disadvantageous in the case of certain active substances that are chemically changed very quickly in the liver and can thus lose their original effect.
  2. Lungs: Here it is also possible that certain active ingredients are retained, which are then no longer available to the bloodstream in sufficient quantities.

 

Substances whose effectiveness is weakened by this passage are better administered in a different way. The advantage of the oral form of application is that through skilful galenic processing drug forms can be produced that meet various human needs. If the gastric mucosa is sensitive, e.g. tablets are provided with enteric coatings so that the active ingredient is only released in the small intestine. The stomach is bypassed and protected as an absorption site.

 

Tips on handling tablets.

In the case of oral administration, some criteria to be observed influence the absorption from the stomach and intestines:
  • An empty stomach favors the absorption of the active ingredient, while a full stomach slows it down.
  • Food components can have a negative effect on the absorption of active ingredients, e.g. fat delays absorption.
  • Hot food accelerates gastric emptying into the small intestine, so that drugs that only dissolve in the intestine work more quickly.
  • Chemical reactions of an active ingredient with food components, e.g. B. Calcium are to be observed. This is the case with some antibiotics, e.g. the tetracyclines. Together with calcium they form a compound that is difficult to absorb. Therefore, these antibiotics should not be taken at the same time as dairy products.

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