What are the chemical properties of quercetin

Quercetin: natural helper for inflammation, allergies and more

Andres, S. et al. (2018): Safety Aspects of the Use of Quercetin as a Dietary Supplement. Mol Nutr Food Res. Jan; 62 (1). https://www.ncbi.nlm.nih.gov/pubmed/29127724, accessed on: May 25, 2018.

Bae, S.C. et al. (2009): Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients. J Am Coll Nutr. Feb; 28 (1): 56-62. https://www.ncbi.nlm.nih.gov/pubmed/19571161, accessed on: April 23, 2018.

Bohm, U. et al. (2012): Interactions with CPY3A4. DAZ 2012, No. 40, p. 58. https://www.deutsche-apotheker-zeitung.de/daz-az/2012/daz-40-2012/interaktion-mit-cyp3a4, accessed on: July 16, 2018.

Brito, A.F. et al. (2015): Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics? Curr Med Chem.; 22 (26): 3025-39. https://www.ncbi.nlm.nih.gov/pubmed/26264923, accessed on: May 27, 2018.

Roar. V. et al. (2015): Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertension: a randomized double-blinded placebo-controlled cross-over trial. Br J Nutr. Oct 28; 114 (8): 1263-77. https://www.ncbi.nlm.nih.gov/pubmed/26328470, accessed on: April 21, 2018.

Costa, L.G. et al. (2016): Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxid Med Cell Longev.; 2016: 2986796. https://www.ncbi.nlm.nih.gov/pubmed/26904161/, accessed on: April 19, 2018.

Cruz-Correa, M. et al. (2006): Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol. Aug; 4 (8): 1035-8. https://www.ncbi.nlm.nih.gov/pubmed/16757216, accessed on: April 18, 2018.

Cruz-Correa, M. et al. (2006): Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol. Aug; 4 (8): 1035-8. https://www.ncbi.nlm.nih.gov/pubmed/16757216, accessed on: April 27, 2018.

Darband, S.G. et al. (2018): Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer. J Cell Physiol. 2018 Sep; 233 (9): 6544-6560. https://www.ncbi.nlm.nih.gov/pubmed/29663361, accessed on: April 17, 2018.

Devipriya, S. et al. (2006): Suppression of tumor growth and invasion in 9,10 dimethyl benz (a) anthracene induced mammary carcinoma by the plant bioflavonoid quercetin. Chem-Biol. Interact.; 162: 106-113. https://www.sciencedirect.com/science/article/pii/S0009279706000792?via%3Dihub, accessed on: May 25, 2018.

Dower, J. et al. (2015): Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre) Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial. J Nutr. Jul; 145 (7): 1459-63. https://www.ncbi.nlm.nih.gov/pubmed/25972527, accessed on: May 25, 2018.

Edwards, R.L. et al. (2007): Quercetin reduces blood pressure in hypertensive subjects. J Nutr. Nov; 137 (11): 2405-11. https://www.ncbi.nlm.nih.gov/pubmed/17951477, accessed on: April 21, 2018.

Egert, S. et al. (2008): Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr. Sep; 138 (9): 1615-21. https://www.ncbi.nlm.nih.gov/pubmed/18716159, accessed on: April 20, 2018.

Egert, S. et al. (2009): Quercetin reduces systolic blood pressure and plasma oxidized low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009 Oct; 102 (7): 1065-74. https://www.ncbi.nlm.nih.gov/pubmed/19402938, accessed on: April 21, 2018.

Garelnabi, M. et al. (2014): Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation. J Int Soc Sports Nutr. May 27; 11:22. https://www.ncbi.nlm.nih.gov/pubmed/24890098, accessed on: April 21, 2018.

Guo, Y. et al. (2013): Dietary fat increases quercetin bioavailability in overweight adults. Mol Nutr Food Res. 2013 May; 57 (5): 896-905. https://www.ncbi.nlm.nih.gov/pubmed/23319447, accessed on: 05.07.2018.

Habtemariam, S. & Belai, A. (2018): Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin. Mini Rev Med Chem.; 18 (3): 234-243. https://www.ncbi.nlm.nih.gov/pubmed/28117024, accessed on: April 23, 2018.

Heinz., S.A. et al. (2010): Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial. Pharmacol Res. Sep; 62 (3): 237-42. https://www.ncbi.nlm.nih.gov/pubmed/20478383, accessed on: May 25, 2018.

Helms, S. & Miller, A.D. (2006): Natural Treatment of Chronic Rhinosinusitis. Alternative Medicine Review, Vol. 11/3: http://www.altmedrev.com/archive/publications/11/3/196.pdf, accessed on: April 22, 2018.

Hirano, T. et al. (2009): Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. Sep; 58 (3): 373-82. https://www.ncbi.nlm.nih.gov/pubmed/19454839, accessed on: April 22, 2018.

Hollmann, P.C. et al. (1995): Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. The American Journal of Clinical Nutrition, Volume 62, Issue 6, 1 December 1995, Pages 1276–1282, https://doi.org/10.1093/ajcn/62.6.1276, accessed on: April 20, 2018.

Hubbard, G.P. et al. (2006): Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. Br J Nutr. Sep; 96 (3): 482-8. https://www.ncbi.nlm.nih.gov/pubmed/16925853, accessed on: May 25, 2018.

Ishizawa, K. et al. (2011): Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J Pharmacol Sci .; 115 (4): 466-70. https://www.ncbi.nlm.nih.gov/pubmed/21436601, accessed on: April 20, 2018.

Javadi, F. et al. (2017): The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. J Am Coll Nutr. Jan; 36 (1): 9-15. https://www.ncbi.nlm.nih.gov/pubmed/27710596, accessed on: April 23, 2018.

Jeong, J.H. et al. (2009): Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem. Jan 1; 106 (1): 73-82. https://www.ncbi.nlm.nih.gov/pubmed/19009557/, accessed on: April 27, 2018.

Jeong, S.M. et al. (2012): Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db / db mice. Nutr Res Pract. Jun; 6 (3): 201-7. https://www.ncbi.nlm.nih.gov/pubmed/22808343, accessed on: April 21, 2018.

Kanzaki, N. et al. (2012): Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric. Mar 15; 92 (4): 862-9. https://www.ncbi.nlm.nih.gov/pubmed/21969261, accessed on: April 23, 2018.

Kelly, G.S. (2011): Quercetin. Alternative Medicine Review. 16 (2). http://archive.foundationalmedicinereview.com/publications/16/2/172.pdf, accessed on: 05.07.2018.

Kim, H. et al. (2005): Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. Pharm Res. Sep; 22 (9): 1499-509. https://www.ncbi.nlm.nih.gov/pubmed/16132362, accessed on: April 20, 2018.

Kobori, M. et al. (2016): Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice. Mol Nutr Food Res. Feb; 60 (2): 300-12. https://www.ncbi.nlm.nih.gov/pubmed/26499876, accessed on: April 25, 2018.

Lam, T.K. et al. (2010): Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. Carcinogenesis. Apr; 31 (4): 634-42. https://www.ncbi.nlm.nih.gov/pubmed/20044584, accessed on: May 25, 2018.

Larson, A. et al. (2010): Quercetin: A Treatment for Hypertension? A Review of Efficacy and Mechanisms. Pharmaceuticals (Basel). Jan; 3 (1): 237-250. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991028/, accessed on: April 21, 2018.

Larson, A.J. et al. (2012): Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms. Adv Nutr. Jan; 3 (1): 39-46. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262612/, accessed on: April 17, 2018.

Lee, J.S. et al. (2016): Onion peel extract reduces the percentage of body fat in overweight and obese subjects: a 12-week, randomized, double-blind, placebo-controlled study. Nutr Res Pract. Apr; 10 (2): 175-81. https://www.ncbi.nlm.nih.gov/pubmed/27087901, accessed on: April 25, 2018.

Lee, S.G. et al. (2017): Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes. J Nutr Biochem. Apr; 42: 62-71. https://www.ncbi.nlm.nih.gov/pubmed/28131896, accessed on: April 25, 2018.

Li, Y.L. et al. (2017): Quercetin protects neuronal cells from oxidative stress and cognitive degradation induced by amyloid β-peptide treatment. Mol Med Rep. Aug; 16 (2): 1573-1577. https://www.ncbi.nlm.nih.gov/pubmed/28586024, accessed on: April 18, 2018.

Loke, W.M. et al. (2008): Pure dietary flavonoids quercetin and (-) - epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. At J Clin Nutr. 2008 Oct; 88 (4): 1018-25. https://www.ncbi.nlm.nih.gov/pubmed/18842789, accessed on: April 21, 2018.

Lu, N.T. et al. (2016): A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C. Phytother Res. 2016 Jan; 30 (1): 160-8. https://www.ncbi.nlm.nih.gov/pubmed/26621580, accessed on: June 20, 2018.

Matsuno, H. et al. (2009): Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis. Biosci Biotechnol Biochem. Feb; 73 (2): 288-92. https://www.ncbi.nlm.nih.gov/pubmed/19202302, accessed on: April 23, 2018.

Miller, A.L. (2011): The etiologies, pathophysiology, and alternative / complementary treatment of asthma. Aging Med Rev. Feb; 6 (1): 20-47. https://www.ncbi.nlm.nih.gov/pubmed/11207455, accessed on: April 22, 2018.

Mitchell, A.E. et al. (2007): Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes. J Agric Food Chem. Jul 25; 55 (15): 6154-9. https://www.ncbi.nlm.nih.gov/pubmed/17590007, accessed on: April 17, 2018

Mlcek. J. et al. (2016): Quercetin and Its Anti-Allergic Immune Response. Molecules. May 12; 21 (5). https://www.ncbi.nlm.nih.gov/pubmed/27187333, accessed on: April 22, 2018.

Mohammadi-Sartang, M. et al. (2017): Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. Sep; 71 (9): 1033-1039. https://www.ncbi.nlm.nih.gov/pubmed/28537580, accessed on: April 19, 2018.

Murakami, A. et al. (2008): Multitargeted cancer prevention by quercetin. Cancer Lett. Oct 8; 269 (2): 315-25. https://www.ncbi.nlm.nih.gov/pubmed/18467024, accessed on: April 27, 2018.

Najafzadeh, M. et al. (2009): Flavonoids inhibit the genotoxicity of hydrogen peroxide (H (2) O (2)) and of the food mutagen 2-amino-3-methylimadazo [4,5-f] -quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD). Mutagenesis. Sep; 24 (5): 405-11. https://www.ncbi.nlm.nih.gov/pubmed/19553277, accessed on: April 23, 2018.

Niedzwiecki, A. et al. (2016): Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients. Sep; 8 (9): 552. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037537/#B38-nutrients-08-00552, accessed on: May 25, 2018.

Pattanashetti, L.A. et al. (2017): Evaluation of the neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. Indian J Pharmacol. Jan-Feb; 49 (1): 60-64. https://www.ncbi.nlm.nih.gov/pubmed/28458424, accessed on: April 18, 2018.

Pfeuffer, M. et al. (2013) Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms. Nutr Metab Cardiovasc Dis. May; 23 (5): 403-9. https://www.ncbi.nlm.nih.gov/pubmed/2211895, accessed on: April 25, 2018.

Rivera, L. et al. (2008): Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring). Sep; 16 (9): 2081-7. https://www.ncbi.nlm.nih.gov/pubmed/18551111, accessed on: April 25, 2018.

Scheller, S. et al. (2000): Effect of quercetin, caffeic acid and caffeic acid phenylethyl ester, solubilized in non-ionic surfactants, on histamine release in vivo and in vitro. Drug research. Jan; 50 (1): 72-6. https://www.ncbi.nlm.nih.gov/pubmed/10683719, accessed on: April 22, 2018.

Serban, M.C. et al. (2016): Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. Jul 12; 5 (7). https://www.ncbi.nlm.nih.gov/pubmed/27405810, accessed on: April 21, 2018.

Shi, Y. & Williamson, G. (2016): Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomized, double-blinded, placebo-controlled, cross-over trial. 1. Br J Nutr. Mar 14; 115 (5): 800-6. https://www.ncbi.nlm.nih.gov/pubmed/26785820, accessed on: May 25, 2018.

Shoskes, D.A. & Nickel, J.C. (2011): Quercetin for chronic prostatitis / chronic pelvic pain syndrome. Urol Clin North Am. Aug; 38 (3): 279-84. https://www.ncbi.nlm.nih.gov/pubmed/21798389, accessed on: April 23, 2018.

Shoskes, D.A. et al. (1999): Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology. Dec; 54 (6): 960-3. https://www.ncbi.nlm.nih.gov/pubmed/10604689, accessed on: April 23, 2018.

Bhagwat, S. et al. (2011): USDA Database for the Flavonoid Content of Selected Foods, Release 3 (PDF). U.S. Department of Agriculture. 2011. https://www.ars.usda.gov/ARSUserFiles/80400525/Data/Flav/Flav_R03.pdf, accessed on: April 23, 2018

Valensi, P. et al. (2005): A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. Sep-Oct; 19 (5): 247-53. https://www.ncbi.nlm.nih.gov/pubmed/16112498, accessed on: April 21, 2018.

Zhang, C. et al. (2018): Mechanistic insights into the inhibition of quercetin on xanthine oxidase. Int J Biol Macromol. Jun; 112: 405-412. https://www.ncbi.nlm.nih.gov/pubmed/29410028, accessed on: May 25, 2018.

Zhang, J.Y. et al. (2015): Combinational Treatment of Curcumin and Quercetin against Gastric Cancer MGC-803 Cells in Vitro. Molecules, 20 (6), 11524-11534. http://www.mdpi.com/1420-3049/20/6/11524/htm, accessed on: April 18, 2018.

Zhao, Y. et al. (2017): The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity. Oxid Med Cell Longev .; 2017: 1459497. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613708/#B54, accessed on: April 25, 2018.